In this paper, the research progress of stimulus-responsive application systems based on shape memory polymers (SMPs) is systematically reviewed. SMPs have shown great potential in the field of drug-controlled release due to their excellent biocompatibility, degradability and shape memory ability. With the continuous advancement of biomedical engineering and intelligent material science, SMP-based drug delivery systems have emerged as a promising strategy to achieve precise spatial and temporal control of drug release. These systems can respond to specific physiological or external stimuli, thereby improving therapeutic efficacy while minimizing side effects. This paper focuses on the design of SMP system under various stimuli-responsive mechanisms such as thermal response, enzyme response, magnetic response, light response and acoustic response, including multi-responsive fibers, electrospun membranes, balloons and other structural forms, and systematically evaluates its performance from the aspects of biocompatibility, drug release kinetics, on-demand release ability and physical properties. In addition, this paper also discusses the advantages and challenges of various response mechanisms, and puts forward prospects for the construction of multi-mode collaborative response systems, the promotion of animal and clinical experiments, and large-scale production in the future.
Research Article
Open Access